منابع مشابه
A glow of HLA typing in organ transplantation
The transplant of organs and tissues is one of the greatest curative achievements of this century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the main goal of the immune response is the MHC (major histocompatibility complex) molecules expressed on the surface of donor cells. Cell surface molecules that induce an anti...
متن کاملHLA Mismatching Strategies for Solid Organ Transplantation – A Balancing Act
HLA matching provides numerous benefits in organ transplantation including better graft function, fewer rejection episodes, longer graft survival, and the possibility of reduced immunosuppression. Mismatches are attended by more frequent rejection episodes that require increased immunosuppression that, in turn, can increase the risk of infection and malignancy. HLA mismatches also incur the ris...
متن کاملAssociation between donor-recipient HLA-DR compatibility and cytomegalovirus hepatitis and chronic rejection in liver transplantation.
P REVIOUS studies in liver transplant patients have demonstrated that liver allografts matched for HLA. especially HLA-DR, have lower survival rates, raising the concept that HLA plays a dualistic role in liver transplan-tation. HLA matching will reduce rejection but may augment other major histocompatibility complex (MHC) restricted cellular immune mechanisms of liver allograft injury. 1.2 The...
متن کاملHLA compatibility index: does it have a role in patients after heart transplantation?
AIMS To determine the impact of HLA compatibility measured by the Compatibility Index, on survival, rate of rejections, malignancies and infections in patients after heart transplantation (HTx). METHODS We carried out a retrospective analysis of 182 consecutive patients who underwent heart transplantation in our center from January 2001 to April 2010. According to degree of HLA-A, B and DR ma...
متن کاملChallenges in Organ Transplantation
Organ transplantation has progressed tremendously with improvements in surgical methods, organ preservation, and pharmaco-immunologic therapies and has become a critical pathway in the management of severe organ failure worldwide. The major sources of organs are deceased donors after brain death; however, a substantial number of organs come from live donations, and a significant number can also...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2001
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/16.suppl_6.147